Description
Chinese name: dytaphone propionate ester
English name: Dromostanolone propionate
Chinese alias: bow he androsterone heptanoic acid ester | different dragon, too
Dromostanolone propionate (Drostanolone propionate) is a compound with anti-breast cancer activity. Dromostanolone propionate inhibited estradiol-17ß uptake in tumors, but had no significant effect on the uptake in normal breast tissue. The Dromostanolone propionate pellet causes weight gain in animals and suppresses estrus in females
Drotaandrosterone propionate, Chinese alias isomestellone, hydroxymeandrosterone, is a medical intermediate, white or white like crystalline powder, can be from 9, 11-dehydrogen-17A-methyl-testosterone as raw material, with lithium chloride, N-chloro-succinimide reaction to produce 9A, 11-dichloro-17A-methyl-95 testosterone, It was further esterified with propionate to produce 9A, 11-dichloro-17A-methyl-95 testosterone propionate, namely, drotaandrosterone propionate. Preparation of drotaandrosterone propionate was prepared as follows: step 1:0.781g of 9, 11-dehydrogen-17a-methyl-testosterone and 4.0g of lithium chloride were dissolved in 50cm3 glacial acetic acid. The mixture was cooled to 0-5 ° C and 0.385 Gn-chlorinated succinimide was added under stirring, followed immediately by a tetrahydrofuran solution of 0.Chemicalbook105g hydrogen chloride. After stirring for 3-4 hours at room temperature, the reaction mixture was cycled and then poured into 500cm3 of water to precipitate the reaction products. The product was filtered out, washed with plenty of water and vacuum dried. 9A, 11-dichloro-17A-methyl-95 testosterone was obtained by recrystallization from acetone-ethyl acetate in 0.95g crude product. Step 2: Dissolve 0.371g of 9A, 11-dichloro-17A-methyl-95 testosterone in 10cm3 pyridine. After cooling, the reaction solution is largely evaporated in vacuum. The residue was dissolved in methylene chloride and washed to neutral with dilute hydrochloric acid, soda and water. The dichloromethane solution was concentrated to obtain pure drotaandrosterone propionate.
English name: Dromostanolone propionate
Chinese alias: bow he androsterone heptanoic acid ester | different dragon, too
Dromostanolone propionate (Drostanolone propionate) is a compound with anti-breast cancer activity. Dromostanolone propionate inhibited estradiol-17ß uptake in tumors, but had no significant effect on the uptake in normal breast tissue. The Dromostanolone propionate pellet causes weight gain in animals and suppresses estrus in females
Drotaandrosterone propionate, Chinese alias isomestellone, hydroxymeandrosterone, is a medical intermediate, white or white like crystalline powder, can be from 9, 11-dehydrogen-17A-methyl-testosterone as raw material, with lithium chloride, N-chloro-succinimide reaction to produce 9A, 11-dichloro-17A-methyl-95 testosterone, It was further esterified with propionate to produce 9A, 11-dichloro-17A-methyl-95 testosterone propionate, namely, drotaandrosterone propionate. Preparation of drotaandrosterone propionate was prepared as follows: step 1:0.781g of 9, 11-dehydrogen-17a-methyl-testosterone and 4.0g of lithium chloride were dissolved in 50cm3 glacial acetic acid. The mixture was cooled to 0-5 ° C and 0.385 Gn-chlorinated succinimide was added under stirring, followed immediately by a tetrahydrofuran solution of 0.Chemicalbook105g hydrogen chloride. After stirring for 3-4 hours at room temperature, the reaction mixture was cycled and then poured into 500cm3 of water to precipitate the reaction products. The product was filtered out, washed with plenty of water and vacuum dried. 9A, 11-dichloro-17A-methyl-95 testosterone was obtained by recrystallization from acetone-ethyl acetate in 0.95g crude product. Step 2: Dissolve 0.371g of 9A, 11-dichloro-17A-methyl-95 testosterone in 10cm3 pyridine. After cooling, the reaction solution is largely evaporated in vacuum. The residue was dissolved in methylene chloride and washed to neutral with dilute hydrochloric acid, soda and water. The dichloromethane solution was concentrated to obtain pure drotaandrosterone propionate.
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